PDB ID 2AZ5 Structure of TNF-alpha

3D Model

2AZ5

http://www.rcsb.org/pdb/explore.do?structureId=2az5

Crystal Structure of TNF-alpha with a small molecule inhibitor

DOI: 10.2210/pdb2az5/pdb

Classification: CYTOKINE

Deposited: 2005-09-09 Released: 2005-11-29

Deposition author(s): He, M.M.

Organism: Homo sapiens

Expression System: Escherichia coli BL21(DE3)

Structural Biology Knowledgebase: 2AZ5 (1 model >16 annotations) SBKB.org

Experimental Data Snapshot

Method: X-RAY DIFFRACTION Resolution: 2.1 Å R-Value Free: 0.278 R-Value Work: 0.220

Small-molecule inhibition of TNF-alpha.

He, M.M., Smith, A.S., Oslob, J.D., Flanagan, W.M., Braisted, A.C., Whitty, A., Cancilla, M.T., Wang, J., Lugovskoy, A.A., Yoburn, J.C., Fung, A.D., Farrington, G., Eldredge, J.K., Day, E.S., Cruz, L.A., Cachero, T.G., Miller, S.K., Friedman, J.E., Choong, I.C., Cunningham, B.C.

Science 310: 1022-1025 (2005)

PubMed: 16284179 Search on PubMed DOI: 10.1126/science.1116304