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More model informationThe conformation of the envelope glycoprotein involved in membrane fusion.
When dengue virus is carried into the cell and into lysozomes, the acidic environment causes the protein to snap into a different shape, assembling into trimeric spike. Several hydrophobic amino acids (colored bright red) at the tip of the spike insert into the lysozomal membrane and cause the virus membrane to fuse with lysozome. This releases the RNA into the cell and infection starts.
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