Brdt is a testis specific bromodomain region that possesses BD1, which can bind with specificity to diacetylated histone tails H4. This model is designed to illustrate why BD1 has this ability through its interactions with H4. The tour provides overview of the the pocket in which peptides bind and interact with one another. An in depth examination of the groups that interact H4 as well as the surrounding water molecules. It will also explore the effect of the bromodomain configuration on binding affinity, and how it essentially facilitates cooperative binding between two histone PTMs. This model is derived from the pdb article code 2WP2 (DOI:10.1038/nature08397). BD1 is represented with green in its cartoon form, with the residues that interact with H4 highlighted via their line structure, with the carbon atoms in cyan. H4’s carbons are in hot pink. The elements are coded as follows: carbon (pink/cyan), nitrogen (dark blue), oxygen (red), van der Waal’s contacts (dotted yellow), water molecule (red x)
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