Complex I NADH: Ubiquinone Oxidoreductase3D ModelNoAI
Complex I (CI) is the entry point for electrons into the electron transport chain (ETC) protein complexes. It is composed of a hydrophobic arm (orange) that anchors it to the mitochondrial membrane, and a hydrophilic arm (shades of blue and red) that sits in the mitochondrial matrix.
CI catalyzes the transport of electrons from NADH through the reduction of FMN. Electrons are then passed through a series of iron-sulfur clusters to ubiquinone. The movement of electrons up through CI is coupled with the translocation of protons across the mitochondrial inner membrane.
This model was created using ChimeraX from cryo-electron microscopy structure data in the Protein Data Bank (PDB ID 5XTD). PDB DOI: 10.2210/pdb5XTD/pdb & https://www.cgl.ucsf.edu/chimerax/
Guo R, Zong S, Wu M, Gu J & Yang M (2017). Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2. Cell 170, 1247-1257.e12. https://doi.org/10.1016/j.cell.2017.07.050
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