ERN1 Alpha Fold Structure

3D Model

The structure of ERN1 is useful when studying the protein-protein interactions that lead to the stress and unfolded protein responses in the endoplasmic reticulum (ER), as it allows one to visualise the domains that may be responsible for interactions with other proteins. The AlphaFold model of ERN1 was used to show all the domains in this investigation (1), as no structures exist for the crystallised protein in its entirety.

References:

J. Jumper et al., Highly accurate protein structure prediction with AlphaFold. Nature 596, 583-589 (2021).

J. Zhou et al., The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc. Natl. Acad. Sci. U. S. A. 103, 14343-14348 (2006).

M. M. Ali et al., Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 30, 894-905 (2011).