Triangles: 14.1k
Vertices: 7.3k
More model informationMolecular structure of human insulin is made up of 51 amino acids arranged in two peptide chains named an A-chain and a B-chain. The chains are linked together by two disulfide bonds.
Insulin is produced in the pancreas. It is the hormone that controls glucose levels in the blood. Dorothy Hodgkin determined the structure of insulin using X-ray diffraction in 1969.
The model was built using ChimeraX from X-ray diffraction crystal structure data in the Protein Data Bank (PDB ID 1TRZ). DOI: 10.2210/pdb1TRZ/pdb & https://www.cgl.ucsf.edu/chimerax/
‘Crystallographic evidence for dual coordination around zinc in the T3R3 human insulin hexamer.’ Ciszak, E., Smith, G.D. (1994) Biochemistry 33: 1512-1517. PubMed: 831227 DOI: 10.1021/bi00172a030.
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