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Iodothyronine Deiodinase - PNAS (2014)
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
Schweizer, U., Schlicker, C., Braun, D., Kohrle, J., Steegborn, C.
Journal: (2014) Proc.Natl.Acad.Sci.USA 111: 10526
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PubMed Abstract: Local levels of active thyroid hormone (3,3’,5-triiodothyronine) are controlled by the action of activating and inactivating iodothyronine deiodinase enzymes. Deiodinases are selenocysteine-dependent membrane proteins catalyzing the reductive elimination of iodide from iodothyronines through a poorly understood mechanism. We solved the…