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More model informationJMJD2A is a demethylated enzyme that catalyzes the demethylation of Lys9 and Lys35 of a range of other histones, H3, such as H3K9me3.
This enzyme methylates mainly by depositating the trimethyl-lysine to be reacted into the methyl-ammonium binding pocket through main chain hydrogen bonding and hydrophobic interactions.
This 3D model mainly introduces methylammonium binding pockets, some sites that interact with histone H3 and a mutation site that increases enzyme activity.
Mar 19th 2023
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