As the party begins and the party streamers are blown, blood glucose levels begin to rise, but blood homeostasis must be maintained ,so how does the MafA protein combat this increase in serum glucose?
The MafA protein is a basic leucine rich zipper transcription factor (bZIP), part of the AP1 superfamily. It is an activator of the insulin gene in pancreatic β-cells, in the presence of high blood glucose. The protein regulates insulin gene expression by binding to the insulin promoter at the consensus maf-recognition elements (MAREs) and induces insulin transcription.
DNA - dark grey. MafA subunit A - pale yellow, MafA subunit B - green.
In this tour we look at how the MafA protein would bind to the DNA to induce insulin to control the concentration of serum glucose.
https://pubs.acs.org/doi/10.1021/bi301248j https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189696/
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