MB Dof MBD4 - Final Model

3D Model

Methyl-CpG Binding Domain proteins (MBDs) are tasked with recognising and binding to the methylated CpG sequences of DNA, and subsequently recruit other proteins for the purposes of transcriptional regulation and/or chromatin modification. In this tour, we will examine the Methyl-CpG Binding Domain of MBD4. MBD4 is unique because in addition to reading methylation marks on CpG DNA, it can also recognise when the Cytosine in such marks has deaminated to become a Thymine, and correct the mismatch.

In this tour we begin with how MBD4 holds onto DNA, we will see how it recognises the CpG sequence and finally we will look at the features which contribute to MBD4’s uniqueness among other members of its family.

This tour was created entirely based on a 2013 article by Otani et. al. DOI: https://doi.org/10.1074/jbc.M112.431098