Microcytes

3D Model

Microcytes are erythrocytes measuring less than 5 microns in diameter, compared to the normal average size of 7 microns. Two of the three cells here are microcytes, hopefully it’s obvious which ones! They are commonly associated with iron deficiency, as a result of which, haemoglobin production is impaired. This leads to the production of smaller, often paler, erythrocytes although good luck finding a thorough explanation of why reduced haemoglobin should make cells smaller, most sources just state it as fact. It’s likely that the signalling systems controlling cell differentiation and size are linked to iron availability. Other factors can also cause microcytosis, not least chronic infection, possily as a by-product of the body trying to hide its iron supplies away from pathogens which also depend on iron.