This model showcases a DNA-binding transcription regulator (ZFP568) that binds to DNA via an 10-zinc finger array. The model uses the PDB structure 5V3J, which was firstly coloured and edited in PyMOL. This model highlights the various zinc fingers (ZFs) and their properties through coloring and annotations. The model firstly depicts the conventional 1-finger-3-base ZF, commonly seen in most ZF transcription factors. Each subsequent ZF shown deviates from this convention. The model shows ZFs that bind to two bases, four bases, thymines on a “non-recognition” strand, and a non-DNA binding ZF. All these different interactions arose due to a shortened minor groove, which supports the notion ZF arrays may be adaptable in response to changes in DNA conformation. The purpose of this model was to showcase these different interactions and to highlight the flexibility and adaptability of zinc finger arrays, as well as the importance of structural and functional diversity of ZF proteins.
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