Myosin X - Stroke Cycle

3D Model

Myosin-X is a motor protein that transports cargo inside the cells by “walking” along the cytoskeleton. Movement of myosin-X is driven by ATP hydrolysis, in a unique mechanism that resembles walking or stepping. The walking mechanism of myosin-X is known to be distinct from other walking myosins such as myosin-V.

Myosin 3D model based on following PDB surfaces: Cargo domain: 3au5 Light chains: 2fce, Coil: 4xa3, Motor: 1g8x.

Actin 3D model based on PDB surface 3jbj.

All parts of the proteins were assembled and animated in #blender.

Information extracted from : (1) S. Nagy, B.L. Ricca, M.F. Norstrom, D.S. Courson, C.M. Brawley, P.A. Smithback, and R.S. Rock. Proc. Natl. Acad. Sci. U.S.A. 2008. 105(28):9616-20.

(2) B.L. Ricca, and R.S. Rock. Biophys. J. 2010. 99(6):1818-26.

For more information on Myosins and other molecular machines, visit our wiki: http://www.mechanobio.info/topics/cytoskeleton-dynamics/cytoskeleton-dependent-intracellular-transport/