P300 structure and some key features

3D Model

P300 is histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. Mutations in their catalytic ‘cores’ are linked to genetic disorders, including cancer. p300 regulates transcription by directly binding to transcription factors. This interaction is managed by one or more of the p300 domains: the nuclear receptor interaction domain (RID), the CREB and MYB interaction domain (KIX), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD).

p300 is thought to increase gene expression in three ways: 1.by relaxing the chromatin structure at the gene promoter through their intrinsic histone acetyltransferase (HAT) activity. 2.recruiting the basal transcriptional machinery including RNA polymerase II to the promoter. 3.acting as adaptor molecules.