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More model informationPap1 is an AP-1 like transcription factor found in fission yeast (Scizosaccharomyces pombe). PAP1 is an activator that binds to the enhancer regions of genes involved in the oxidative stress response and in multidrug resistance, such as ABC transporters. Activation of Pap1 is regulated by the oxidation of cystein residues in the cell.
The protein is a dimer of two bZIP motifs joined by a leucine zipper. Both monomers contain the Pap1 signature sequence NXXAQXXFR, and bind in the major grooves of the DNA molecule.
This model shows two identical Pap1 proteins bound to theiir binding sequence on DNA molecules. This tour outlines the key structural and functional features of Pap1.
References: https://doi.org/10.1038/82822
Apr 4th 2021
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