Phosphatidate phosphatase lipin 2 (LPIN2) is a human protein encoded by the LPIN2 gene, responsible for regulation of lipid metabolism and energy homeostasis in the endoplasmic reticulum. LPIN2 functions as a magnesium-dependent phosphatidate phosphatase enzyme as part of triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis. This means, with a Mg2+ cofactor, LPIN2 catalyses the removal of a phosphate group from phosphatidic acid, converting it into diacylglycerol (Forward reaction: 1,2-diacyl-sn-glycero-3-phosphate + H2O ―> a 1,2-diacyl-sn-glycerol + phosphate). Expression of LPIN2 is predominantly in tissues with active lipid metabolism, such as adipose tissue, liver, and skeletal muscle, but is also expressed in the lungs, kidneys, placenta, spleen, thymus, lymph nodes, prostate, testes, small intestine, and colon.
Have a look through the annotations to learn more on the structure of the LPIN2 protein.
Comments