Siderocyte

3D Model

Each haemoglobin protein molecule contains four iron atoms, one in each globin chain, held in a specific orientation. These iron atoms are essential for binding oxygen molecules so they can be carried round the body by erythrocytes. If there are defects in how the iron is packaged into the haemoglobin while erythrocytes are being formed, the iron forms deposits in the cytoplasm. These can be readily identified by a histological stain. The affected cells are unable to transport oxygen efficiently resulting in anaemia.