CDX2 is a transcription factor in intestinal epithelial cells, regulating critical activities such as proliferation and regeneration.
The above tutorial will go through the DNA binding domain of the homo sapien CDX2, residues 187-256, where the intricacies of its binding to the major groove of DNA will be described, as well as the properties of its N-terminal residues and its polyQ sequence.
Due to the lack of prominent features of the DNA-binding domain, further research was done on the transcriptional regulational of CDX2; which is not described in detail in the tutorial as it is outside the DNA binding domain residues 187-256. Transcriptional regulation of CDX2 is done through the phosphorylation of S-286, which controls its degradation via polyubiquitination.
https://doi.org/10.7554/eLife.32963.001 doi: 10.1146/annurev-pathmechdis-012418-012857 https://doi.org/10.1016/j.bbadis.2010.11.008 https://www.uniprot.org/uniprot/Q99626
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