The Cys2-His2 Zinc Finger Wilms Tumor protein, WT1, bound to DNA.
The protein backbone is shown as a green ribbon, and the DNA backbone and bases are shown in pink. The phosphates of the DNA backbone are shown as sticks. The Zn2+ ion in each of the four zinc fingers is shown as a large pink sphere, with the coordinated four protein side chains, two histidines and two cysteines, shown as sticks.
The protein side chains that nonspecifically interact with the DNA backbone are shown as sticks.
Note the that zinc coordination orients the histidine’s alpha helix to bind in the major groove of the DNA.
Stick colors: carbon = cyan, red = oxygen, blue = nitrogen, white = hydrogen, yellow = sulfur, tan = phosphorous
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