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More model informationThe structural features of the Gcn5p bromodomain are responsible for its binding specificity.
Gcn5p is a histone acetyltransferase (HAT) found in Baker’s yeast (Saccharomyces cerevisiae). This 3D annotation examines the Gcn5p bromodomain, which is responsible for binding to histone tails with already acetylated lysine residues. This includes H4K16ac, which is shown in orange. Following binding, the N-acetyltransferase domain can then acetylate other lysine residues. Overall, it is believed that Gcn5p facilitates the coupling between histone acetylation and chromatin remodelling.
Apr 20th 2019
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