BRD3-BD1 (shown in grey) is a member of the bromodomain and extra-terminal domain (BET) family proteins. The BET family proteins act as transcriptional regulators and as such are able to perform a range of functions such as activate RNA polymerase II machinery, bind to lysine-acetylated histones and transcription factors, and recruit coactivators and transcription factors. Dysfunction of the BET family proteins has been linked to the development of several diseases such as cancer (acute myeloid leukaemia, oestrogen receptor-positive breast cancer, and lymphoma) and inflammatory disorders. Therefore, selective inhibition of the BET family proteins shows promise as a strategy for treating these diseases. 3.1C (shown in multi-colour) is a type of cyclic peptide and is able to act as an inhibitor of BRD3-BD1 due to its potency and selectivity for BRD3-BD1.
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