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More model informationPDB number: 4IB4. G protein-coupled receptors (GPCRs) represent the most prominent class of drug discovery targets owing to their key role in cell signalling events. The 5-hydroxytryptamine 2B (5-HT2B, PDB: 4IB4) receptor, a member of the GPCR family. Consequently, selective 5-HT2B antagonists have been explored as promising therapeutics for migraines, pulmonary arterial hypertension (PAH) and cardiac failure. However, there have been no 5-HT2B antagonists clinically approved up to now. References: DOI: 10.1039/c8md00204e; DOI: 10.1080/00268976.2014.952695
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Sep 4th 2019
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