Welcome to a guided tour of the alpha-conotoxin, Imi, (a cyclic peptide that blocks the transmission of signals from nerves to muscles in animals and humans), as it binds to Acetylcholine Binding Protein, (Ac-AChBP).
Ac-AChBP are homologous to the ligand-binding domains of Nicotinic acetylcholine receptors, (nAChRs) that are found in central and peripheral nervous system, muscle and tissue, and are pharmacologically similar.
Predatory marine snails, Conus Magnus, paralyse their prey with a toxic mix of Imi and Ac-ChBP in their venom, and can provide us with further insight into the relationship between paralysis and pain management within pharmacology and future therapeutical drug design.
This tour will shine a light on five different types of bonding interactions between the Imi and Ac-ChBP and the contribution they make to the overall functionality of the protein.
https://doi.org/10.3390/md14100173 : https://tinyurl.com/4hs8ahwr
https://tinyurl.com/2fhy9me3 : https://tinyurl.com/mryhhap4
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