Botulin neurotoxin bound to its human target SV2

3D Model

The receptor binding domain of Botulinum neurotoxin A bound to beta-helix region of its human target, Synaptic Vesicle Glycoprotein 2 (SV2).

The backbone of the receptor binding domain of Botulinum neurotoxin A is shown in blue ribbons, with select side chains shown as sticks. The region that interacts with the glycosylated region of SV2 is shown in light green. The backbone of the SV2 protein is shown in orange ribbons; the added glycosidic group is shown as chain of sugar rings in sticks.

Note how the botulinum neurotoxin docks on the human receptor both by interacting with SV2 receptor’s glycan groups and also by continuing the receptor’s beta-helix.

From the Protein Data Bank coordinates 5JLV: Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C