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More model informationThe crystal structure of the thrombin-hirudin complex with annotations of 5 key features. The thrombin B-chain is shown in green while the A-chain, which does not participate in binding is shown in magenta. Hirudin is shown in cyan.
Thrombin is a serine protease involved in blood coagulation. It converts fibrinogen into the clottable fibrin. Hirudin is a potent natural inhibitor of thrombin, which represses its function. This inhibitory effect is useful as a medical application for the treatment of thrombotic disorders.
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