This tour presents the interaction between the H4 histone of chromatin and the enzyme required to acetylation, GCN5. Acetylation of lysine 16 on H4 is important for transcritpional competence (Owens et al, 2000). There are a number of key factors involved in this process which have been highlighted here through colour coding.
Lysine 16 (depicted as yellow bubbles) has been made the star of the show as this is where acetylation occurs. Residues providing important internal hydrophobic conditions are presented in red. Magenta is used to highlight how this process can occur in vivo when residues interact with water molecules. Orange is used to highlight Asn407, a residue critical for correct orientation of the H4 histome. Green is used to showcase interactions of residues which demonstrate why lysine 16 is the molecule to undergo acetylation. This is important as Lysine 16 is not the only residue capable of acetylation.
References: https://pubmed.ncbi.nlm.nih.gov/11080160/
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