Feature in August 2015 Molecule of the Month by David Goodsell
http://www.rcsb.org/pdb/101/motm.do?momID=188
Primary Citation:
http://www.rcsb.org/pdb/explore/explore.do?structureId=1gtp
Atomic structure of GTP cyclohydrolase I.
Nar, H., Huber, R., Meining, W., Schmid, C., Weinkauf, S., Bacher, A.
Journal: (1995) Structure 3: 459-466
PubMed: 7663943
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PubMed Abstract:
Tetrahydrobiopterin serves as the cofactor for enzymes involved in neurotransmitter biosynthesis and as regulatory factor in immune cell proliferation and the biosynthesis of melanin. The biosynthetic pathway to tetrahydrobiopterin consists of three steps starting from GTP. The initial reaction is catalyzed by GTP cyclohdrolase I (GTP-CH-I) and involves the chemically complex transformation of the purine into the pterin ring system.
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