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More model information3D model generated from Pymol shows the interaction between Hirudin (turqoise) and Thrombin (large subunit in green, small subunit in purple).
Thrombin is a serine protease that converts fibrinogen into fibrin - an important process during blood coagulation. Hirudin is found in leeches and acts as an inhibitor of thrombin. This inhibition must prevent the conversion of fibrinogen to fibrin and it does this by interacting with thrombin’s fibrinogen binding exosite - blocking binding/docking of fibrinogen. This interaction is also possible by ensuring that the hirudin-thrombin complex is stable and thrombin’s active site is suppressed.
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