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More model informationHIV-1 protease is an aspartic protein which is essential to the life cycle of the HIV viruses. It is a homodimer made up of two identical monomers (shown in yellow and purple) with the active site found between them. HIV-1 protease hydrolyses peptide bonds in immature HIV proteins and allows them to become mature viral proteins. Preventing this process means viruses are unable to infect human cells.
Saquinavir (shown in green) was the first protease inhibitor approved by the FDA for HIV/AIDS treatment. It competitively inhibits HIV-1 protease from cleaving HIV proteins.
The above model shows the key interactions of HIV-1 and saquinavir with notes on the types of interactions.
May 24th 2020
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