Eukaryotic initiation factor 4G (eIF4G) is a key protein in cells that initiates the process of translation via binding to the cap-binding protein eIF4E, which in turn binds the 5’ cap of pre-mRNA and is essential for its maturation through processes such as splicing, 3’ end formation and nuclear export + protection of transcripts. As such, both sides of this interaction have become valuable drug targets when seeking to repress translation in cells, a task that is naturally carried out by 4E-binding proteins. In this model, we will explore the most prominent interactions between eIF4E and eIF4G.
Cap-binding protein (eIF4E) : cyan key residues are shown in white with a mesh outline
Eukaryotic initiation factor 4G (eIF4G) : pink key residues are shown in red
m7GDP (RNA cap analogue) : gold
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