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More model informationThis model (PDB ID: 3RKQ) highlights the structure of NKX2.5, a homeodomain involved in cardiac development, in complex with atrial natriuretic factor (ANF), a target gene. It examines the general structural aspects including its hydrophobic core and N-capping, as well as its interactions with DNA in relation to gene expression. The significance of mutations which are associated with congenital heart diseases are also discussed. The homeodomains are in grey, the DNA in orange, and the colours of the specific residues are noted in the relevant annotation. All information is from Pradhan et al. (2012) DOI: 10.1021/bi300849c
Mar 24th 2023
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