Human TPI

3D Model

Triosephosphate isomerase is a “catalytically perfect” enzyme found in the glycolytic pathway that catalyzes the interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate isomers.

Here is a model of the human TPI enzyme that demonstrates some key features such as residues that are directly involved in or support catalysis, structural components, and a few features (and their consequences) unique to hTPI. This colourful depiction and the accompanying commentary highlight hTPI’s efficiency in structure and mechanism, highlighting why its so highly conserved by evolution.