Human TPI - Capable of good and bad

3D Model

Triosephosphate isomerase (TPI) in Homo sapiens is a metabolic enzyme involved in glycolysis and gluconeogenesis. TPI catalyses the interconversion between dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P), two triose sugars that are intermediates in the glycolytic and gluconeogenic pathways. Given its importance in cellular metabolism, TPI is necessity to human health and function, and this necessity makes deficiency dangerous. This 3D molecular model of human TPI explores the enzyme structure and how this causes issues in instances of point mutation in its sequence.