Human TPI model

3D Model

Triosephosphate isomerase (TPI) an enzyme found in all organisms, is an essential component in glycolytic pathways. It encodes an enzyme, consisting of two proteins that catalyses the reversible isomerization of dihydroxyacetone phosphate (DHAP) to glyceraldehyde 3-phosphate (GAP) in glycolysis and gluconeogenesis. The protein also has many implications to the biochemical world, where there is continuous studies and research on the enzyme. The importance of TPI in glycolysis results in the enzyme forming a target for drug design against parasites found in mammalian blood stream. Understanding the structure of TPI helps people to control any uprising diseases or problems in society and why having certain sequences of residues are crucial in the stabilizing the health of an organism.