Maf Transcription Factors in DNA Complex

3D Model

Maf transcription factors constitute a family of the basic region-leucine zipper (bZip) factors, with intention of regulating several distinct developmental processes, cell differentiation, and the establishment of cell functions. Additionally, Maf has the ability to recognise unusually long DNA motifs, known as Maf recognition element (MARE). In conjunction, Arg57 and Asn61 are two well conserved residues found in the basic region that also contribute to the Maf-specific DNA recognition role (Kurokawa, 2023). Also highlighted are the MafB and c-Maf genes, where the MafB gene is responsible for the segmentation of the hindbrain, while c-Maf has been identified in the liver, renal tubules, and adipocytes (Tsuchiya, 2021).