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More model informationNKX is a transcription factor for cardiac development and maturation which expressed highly in embryonic period. Studies haves found that congenital heart disease is associated with the heterozygous mutation of NKX due to the defects of atrial and ventricular septal and the block of atrioventricular conduction (Pradhan et al., 2012). This 3D model is focusing on NK2.5, the transcription factor from NK2-family, and its binding motif - ANF-242 (site of the atrial natriuretic factor gene). Knowledges are gained from the article: Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA Target.
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