pyMOL - 244 Rubisco Assignment

3D Model

Rubisco has two main functions: carbon fixation, where CO2 is converted to glucose, and photorespiration. O2 molecules are able to bind to Rubisco’s CO2 site which results in photorespiration. CABP is a competitive inhibitor of Rubisco that forms strong H-bonds with the enzyme that can lead to irreversible inhibition. To reactivate Rubisco after inhibition, the protein must use a lot of ATP to remove the CABP from the active site. Occasionally Rubisco binds to Mn(II) instead of Mg(II), which changes the substrate specificity and metabolic outcomes of the protein. When Rubisco is bound to Mn2+ there is a decrease in carboxylation rates and an increase in photorespiration. Lysine-201 is vital for the start of Rubisco and it helps Mg2+ bind to the active sites that act independently from each other. https://pdb101.rcsb.org/motm/1110057430 https://par.nsf.gov/servlets/purl/10057430 https://www.ebi.ac.uk/thornton-srv/m-csa/entry/797/ https://nuku.wgtn.ac.nz/courses/24494/files/4003728/download?download_frd=1