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PAP1 is an AP-1 like transcription factor of yeast which binds to DNA containing the novel consensus sequence ‘TTACGTAA’. This transcription factor has been shown as responsible for the expression of a number of genes involved in the oxidative stress response as well as regulate proteins for energy-dependent transport, involved in multidrug resistance.

PAP1 belongs to the BZIP family of transcription factors which is one of the largest families of Eukaryotic Cell. Even though the amino acid sequence of the BZIP motifs conserve a fairly high degree of homology these proteins are able to recognise and bind a diverse range of DNA sequences.

This guided tour highlights some of the features this dimerized protein employs to achieve its necessary function highlighted above binding as a transscription factor to the novel consensus sequence ‘TTACGTAA’.

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References: 10.1038/82822 10.1101/gad.12.10.1453