This 3D render shows the structure of thrombin when it’s binded to one of its inhibitors, sulfohirudin. Thrombin is shown in white, ions in pink/purple, while sulfohirudin is in yellow.
Thrombin is a protein which is central in the blood coagulatory system. One of the main substrates of thrombin is fibrinogen, which is then converted to fibrin. Thrombin also additionally activates Factor XIII, which then goes on and facilitate cross linked bond formation on each fibrin. 3 of the annotations will let tell you the main components which are crucial to thrombin functioning. Should there be mutations to these parts, conditions like excessive bleeding can occur. One drug which targets thrombin is sulfohirudin. This is used to treat conditions like thrombosis, where thrombin disregulation causes blood clots to block out blood circulation. 2 of the annotations will show the mechanisms which allows this drug to sufficiently inhibit thrombin.
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